Microbes can be used to treat disease in several ways. For an example, microbes can be engineered to produce therapeutic molecules to treat metabolic conditions, kill pathogens and trigger immune responses to cancers. Communities of microbes can also be constructed to treat disease, Native bacteria in mice can also be used as the chassis for persistent and potentially even curative therapeutic changes in the gut and reversing disease pathogens.
Microbes can cause infectious diseases such as flu and measles and contribute to many non-infectious chronic diseases such as some forms of cancer and coronary heart disease. They also can trigger respiratory infections and allergies if they grow in workspaces or at home. Bacterial infections inside of your body can cause serious complications such as sepsis, a life-threatening reaction to an infection that causes organ damage.
(2023 Summer B18 Term) SC166-8C: Microbiology
Instructor: – Dr.Shane
August 01, 2023
Unit 4 Discussion –Beneficial Microbes
After performing a research on this week’s discussion for the beneficial use for microbe in treating disease I found that some beneficial use for a microbe in treating disease is the role of beneficial microbes as a biocontrol agent beneficial microorganisms have the ability to suppress various phytopathogens through a number of ways, such as by producing antibiotics, lytic enzymes, HCN, and siderophore and by competing with pathogens for nutrients and space, thus limiting the availability of nutrients.
(Marasco et al., 2012).
According to The National Library of Medicine coriolus versicolor, a popular traditional Chinese medicinal herb, is widely used in China to treat spleen and liver diseases; however, the beneficial effects of C. Versicolor polysaccharides (CVPs) on nonalcoholic fatty liver disease (NAFLD) remain elusive. CVP altered gut microbiota, predominantly suppressing microbes associated with bile acids both in the serum and cecal contents. In vitro data showed that CVP reduced HFD-induced hyperlipidemia via farnesoid X receptor. Our results improve our understanding of the mechanisms underlying the cholesterol- and lipid-lowering effects of CVP and indicate that CVP is a promising candidate for NAFLD therapy.
I also found this article were in also explains the Prebiotics are compounds that selectively stimulate the growth and activity of beneficial microorganisms. The use of prebiotics is a well-established strategy for managing human gut health. This concept can also be extended to plants where plant rhizosphere microbiomes can improve the nutrient acquisition and disease resistance. However, we lack effective strategies for choosing metabolites to elicit the desired impacts on plant health. In this study, we target the rhizosphere of tomato (Solanum lycopersicum) suffering from wilt disease (caused by Ralstonia solanacearum) as source for potential prebiotic metabolites. We identify metabolites (ribose, lactic acid, xylose, mannose, maltose, gluconolactone, and ribitol) exclusively used by soil commensal bacteria (not positively correlated with R. solanacearum) but not efficiently used by the pathogen in vitro.
Some complications with this strategy preventing its immediate application are Pregnant overweight women are at risk of gestational diabetes affecting the health of the mother and the child, in both the short and long term. Notwithstanding the extensive scientific interest centred on the problem, research efforts have thus far been unable to devise preventive strategies. Recent scientific advances point to a gut microbiota dysbiosis, with ensuing low-grade inflammation as a contributing element, in obesity and its comorbidities.
Tang H, Zha Z, Tan Y, Li Y, Jiao Y, Yang B, Xiong Q, Yin H, Wang H. Extraction and characterization of polysaccharide from fermented mycelia of Coriolus versicolor and its efficacy for treating nonalcoholic fatty liver disease. Int J Biol Macromol. 2023 Jul 25;248:125951. doi: 10.1016/j.ijbiomac.2023.125951. Epub ahead of print. PMID: 37499724.
Wen T, Xie P, Liu H, Liu T, Zhao M, Yang S, Niu G, Hale L, Singh BK, Kowalchuk GA, Shen Q, Yuan J. Tapping the rhizosphere metabolites for the prebiotic control of soil-borne bacterial wilt disease. Nat Commun. 2023 Jul 26;14(1):4497. doi: 10.1038/s41467-023-40184-2. PMID: 37495619; PMCID: PMC10372070.
Isolauri E, Rautava S, Collado MC, Salminen S. Role of probiotics in reducing the risk of gestational diabetes. Diabetes Obes Metab. 2015 Aug;17(8):713-9. doi: 10.1111/dom.12475. Epub 2015 May 20. PMID: 25885278.
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